About SAND domain factorsClass description: A twisted beta-sheet exposes four alpha-helices that are packed against one side of the sheet. Most important for DNA-binding is a KDWK motif at the N-terminus of the third alpha-helix. Residues of this alpha-helix and the KWDK motif contact bases through the major groove, but the alpha-helix does not insert into the major groove. The domain structure of some of the class members is supported by an overlaying zinc coordinating motif. (PMID 11427895, PMID 15649886)
More informationSpecies within this Class: 33
Genera within this Class: 8
LOGO plot of the DNA binding domain
FASTA file of the LogoPlot
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DNA binding domain |
Whole protein |
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FASTA file |
FASTA file |
Phylogenetic tree
Mammalia
These trees (or cladograms, since distances were ignored) were generated with a local installation of PhyML 3.0 (Guindon et al., Systematic Biology, 59(3):307-21, 2010.), by webPRANK at EBI (http://www.ebi.ac.uk/goldman-srv/webprank/), or by the web version of PhyML 3.0 (http://phylogeny.lirmm.fr). The resulting trees were visualized with iTOL v3 (http://itol.embl.de/).
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Phylogenetic tree Mammalia
(slim selection)
To generate these trees, only the TFs were taken from a selected group of mammalian species. As standard, the corresponding human, cow, mouse and Monodelphis TFs were taken if available; occasionally, either species was to replaced or had to be omitted without replacement.
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