About Rel homology region (RHR) factorsTRANSFAC
® class description C0020: The structure of the Rel-type DBD exhibits a bipartite subdomain structure, each subdomain comprising a beta-barrel with five loops that form an extensive contact surface to the major groove of the DNA. Particularly, the first loop of the N-terminal subdomain (the highly conserved recognition loop) performs contacts with the recognition element on the DNA, but other loops are involved. The fact that the main DNA-contacts are made through loops has been suggested to provide a high degree of flexibility in binding to a range of different target sequences. Augmenting interactions are achieved by two alpha-helices within the N-terminal part that form strong minor groove contacts to the A/T-rich center of the B-element. In p65, the sequence between both alpha-helices is much shorter and even helix 2 is truncated. The second, C-terminal domain is necessary mainly for protein dimerization.
More informationSpecies within this Class: 39
Genera within this Class: 18
LOGO plot of the DNA binding domain
FASTA file of the LogoPlot
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DNA binding domain |
Whole protein |
| FASTA |
FASTA file |
FASTA file |
Phylogenetic tree Mammalia
(slim selection)
To generate these trees, only the TFs were taken from a selected group of mammalian species. As standard, the corresponding human, cow, mouse and Monodelphis TFs were taken if available; occasionally, either species was to replaced or had to be omitted without replacement.
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