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Classification of Transcription Factors in Mammalia

About TFClass

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Family:

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1 Basic domains
2 Zinc-coordinating DNA-binding domains
- 2.1 Nuclear receptors with C4 zinc fingers
- 2.2 Other C4 zinc finger-type factors
- 2.3 C2H2 zinc finger factors
  - 2.3.1 Three-zinc finger Krüppel-related
    - 2.3.1.1 Sp1-like
    - 2.3.1.2 Kr-like
    - 2.3.1.3 EGR
      - 2.3.1.3.1 EGR1
      - 2.3.1.3.2 EGR2
      - 2.3.1.3.3 EGR3
      - 2.3.1.3.4 EGR4
  - 2.3.2 Other factors with up to three adjacent zinc fingers
  - 2.3.3 More than 3 adjacent zinc fingers
  - 2.3.4 Factors with multiple dispersed zinc fingers
  - 2.3.5 BED zinc finger factors
- 2.5 DM-type intertwined zinc finger factors
- 2.6 CXXC zinc finger factors
- 2.7 C2HC
- 2.8 C3H zinc finger factors
- 2.9 C2CH THAP-type zinc finger factors
3 Helix-turn-helix domains
4 Other all-alpha-helical DNA-binding domains
5 alpha-Helices exposed by beta-structures
6 Immunoglobulin fold
7 beta-Hairpin exposed by an alpha/beta-scaffold
8 beta-Sheet binding to DNA
9 beta-Barrel DNA-binding domains
0 Yet undefined DNA-binding domains

General

Species within this Genus: 27 LOGO plot of the DNA binding sequence

Species specific reports

Jump to human, mouse or rat
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Ailuropoda melanoleuca

Synonyms: giant panda

Outlinks

Ensembl gene: ENSAMEG00000015523
UniProt: D2H0C2

Isoforms and DNA binding domain

Bos taurus

Synonyms: cattle, domestic cow

Outlinks

Ensembl gene: ENSBTAG00000024058

Callithrix jacchus

Synonyms: white-tufted-ear marmoset, white ear-tufted marmoset

Outlinks

Ensembl gene: ENSCJAG00000004136

Canis lupus familiaris

Synonyms: dog, dogs

Outlinks

Ensembl: ENSCAFG00000031530

Cavia porcellus

Synonyms: domestic guinea pig, guinea pig

Outlinks

Ensembl gene: ENSCPOG00000012218

Dasypus novemcinctus

Synonyms: nine-banded armadillo

Outlinks

Ensembl gene: ENSDNOG00000047413

Equus caballus

Synonyms: horse, equine

Outlinks

Ensembl gene: ENSECAG00000010604

Felis catus

Synonyms: domestic cat, cats

Outlinks

Ensembl gene: ENSFCAG00000026704

Gorilla gorilla gorilla

Synonyms: western lowland gorilla, lowland gorilla

Outlinks

Ensembl gene: ENSGGOG00000007221

Homo sapiens

Synonyms: human, man

Outlinks

BioGPS: ENSG00000135625
Ensembl gene: ENSG00000135625
ProteinAtlas: ENSG00000135625 ( with antibody)
TRANSFAC: T05190
UniProt: Q05215

Protein expression pattern:Show tableIsoforms and DNA binding domain

Ictidomys tridecemlineatus

Synonyms: thirteen-lined ground squirrel

Outlinks

Ensembl gene: ENSSTOG00000023961
UniProt: NA

Loxodonta africana

Synonyms: African savanna elephant, African savannah elephant

Outlinks

Ensembl gene: ENSLAFG00000008635
UniProt: NA

Macaca mulatta

Synonyms: Rhesus monkey, rhesus monkeys

Outlinks

Ensembl: ENSMMUG00000000626

Macropus eugenii

Synonyms: tammar wallaby

Outlinks

Ensembl: ENSMEUG00000004509

Microcebus murinus

Synonyms: gray mouse lemur, grey mouse lemur

Outlinks

Ensembl: ENSMICG00000015551

Monodelphis domestica

Synonyms: gray short-tailed opossum

Outlinks

Ensembl gene: ENSMODG00000016968
UniProt: NA

Mus musculus

Synonyms: house mouse, mouse

Outlinks

Ensembl gene: ENSMUSG00000071341
TRANSFAC: T19919
UniProt: Q9WUF2

Isoforms and DNA binding domain

Mustela putorius furo

Synonyms: domestic ferret, ferret

Outlinks

Ensembl: ENSMPUG00000007684

Nomascus leucogenys

Synonyms: northern white-cheeked gibbon, White-cheeked Gibbon

Outlinks

Ensembl gene: ENSNLEG00000010557
UniProt: NA

Ochotona princeps

Synonyms: American pika, southern American pika

Outlinks

Ensembl gene: ENSOPRG00000001342
UniProt: NA

Oryctolagus cuniculus

Synonyms: rabbit, rabbits

Outlinks

Ensembl gene: ENSOCUG00000002443

Otolemur garnettii

Synonyms: small-eared galago

Outlinks

Ensembl gene: ENSOGAG00000030923

Ovis aries

Synonyms: sheep, wild sheep

Outlinks

Ensembl gene: ENSOARG00000011851

Pan troglodytes

Synonyms: chimpanzee

Outlinks

Ensembl gene: ENSPTRG00000012062

Pongo abelii

Synonyms: Sumatran orangutan, orang utan

Outlinks

Ensembl gene: ENSPPYG00000012295

Rattus norvegicus

Synonyms: Norway rat, rats

Outlinks

Ensembl gene: ENSRNOG00000015719
UniProt: G3V7Z9

Isoforms and DNA binding domain

Sus scrofa

Synonyms: pig, wild boar

Outlinks

Ensembl: ENSSSCG00000008301

Select species

Selected the species for which a species report should be shown.

Ailuropoda melanoleuca, giant panda
Bos taurus, cattle
Callithrix jacchus, white-tufted-ear marmoset
Canis lupus familiaris, dog
Cavia porcellus, domestic guinea pig
Choloepus hoffmanni, Hoffmann's two-fingered sloth
Dasypus novemcinctus, nine-banded armadillo
Dipodomys ordii, Ord's kangaroo rat
Echinops telfairi, small Madagascar hedgehog
Equus caballus, horse
Erinaceus europaeus, western European hedgehog
Felis catus, domestic cat
Gorilla gorilla gorilla, western lowland gorilla
Homo sapiens, human
Ictidomys tridecemlineatus, thirteen-lined ground squirrel
Loxodonta africana, African savanna elephant
Macaca mulatta, Rhesus monkey
Macropus eugenii, tammar wallaby
Microcebus murinus, gray mouse lemur
Monodelphis domestica, gray short-tailed opossum
Mus musculus, house mouse
Mustela putorius furo, domestic ferret
Myotis lucifugus, little brown bat
Nomascus leucogenys, northern white-cheeked gibbon
Ochotona princeps, American pika
Ornithorhynchus anatinus, platypus
Oryctolagus cuniculus, rabbit
Otolemur garnettii, small-eared galago
Ovis aries, sheep
Pan troglodytes, chimpanzee
Pongo abelii, Sumatran orangutan
Procavia capensis, Cape rock hyrax
Pteropus vampyrus, large flying fox
Rattus norvegicus, Norway rat
Sarcophilus harrisii, Tasmanian devil
Sorex araneus, European shrew
Sus scrofa, pig
Tarsius syrichta, Philippine tarsier
Tupaia belangeri, northern tree shrew
Tursiops truncatus, bottlenose dolphin
Vicugna pacos, alpaca

Expression table

The table below summarizes the protein expression data from the Protein Atlas. The tissues and cell types are linked to the Cytomer ontology

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Tissue	Cell type	Expression level	Type	Reliability
adrenal gland	glandular tissue	Moderate	Staining	Uncertain
appendix	glandular tissue	Negative	Staining	Uncertain
appendix	lymphoid tissue	Negative	Staining	Uncertain
bone barrow	hematopoetic stem cell	Negative	Staining	Uncertain
breast	glandular tissue	Weak	Staining	Uncertain
bronchi	ciliated call with propulsive function of respiratory tract	Moderate	Staining	Uncertain
cerebellum	granule cell	Negative	Staining	Uncertain
cerebellum		Weak	Staining	Uncertain
cerebellum	purkinje cell	Weak	Staining	Uncertain
cerebral cortex	glial cell of central nervous system	Weak	Staining	Uncertain
cerebral cortex	neuron	Weak	Staining	Uncertain
cervix of uterus	glandular tissue	Negative	Staining	Uncertain
cervix of uterus	squamous epithelial cell	Negative	Staining	Uncertain
colon	glandular tissue	Weak	Staining	Uncertain
duodenum	glandular tissue	Weak	Staining	Uncertain

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