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Classification of Transcription Factors in Mammalia

About TFClass

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Superclass:

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Family:

, Subfamily:

, Genus:

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1 Basic domains
2 Zinc-coordinating DNA-binding domains
3 Helix-turn-helix domains
4 Other all-alpha-helical DNA-binding domains
- 4.1 High-mobility group (HMG) domain factors
  - 4.1.1 SOX-related
    - 4.1.1.1 Group A
    - 4.1.1.2 Group B
    - 4.1.1.3 Group C
    - 4.1.1.4 Group D
    - 4.1.1.5 Group E
    - 4.1.1.6 Group F
      - 4.1.1.6.1 SOX7
      - 4.1.1.6.2 SOX17
      - 4.1.1.6.3 SOX18
    - 4.1.1.7 Group G
    - 4.1.1.8 Group H
    - 4.1.1.9 Further SOX-related
  - 4.1.2 TOX-related
  - 4.1.3 TCF7-related
  - 4.1.4 PBRM1-related
  - 4.1.5 WHSC1-related
  - 4.1.6 UBF-related
  - 4.1.7 TFAM
- 4.2 Heteromeric CCAAT-binding factors
5 alpha-Helices exposed by beta-structures
6 Immunoglobulin fold
7 beta-Hairpin exposed by an alpha/beta-scaffold
8 beta-Sheet binding to DNA
9 beta-Barrel DNA-binding domains
0 Yet undefined DNA-binding domains

General

Species within this Genus: 29 LOGO plot of the DNA binding sequence

Species specific reports

Jump to human, mouse or rat
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Ailuropoda melanoleuca

Synonyms: giant panda

Outlinks

Ensembl gene: ENSAMEG00000016046
UniProt: D2I423

Isoforms and DNA binding domain

Bos taurus

Synonyms: cattle, domestic cow

Outlinks

Ensembl gene: ENSBTAG00000046258

Callithrix jacchus

Synonyms: white-tufted-ear marmoset, white ear-tufted marmoset

Outlinks

Ensembl gene: ENSCJAG00000004168
UniProt: F7EYL6

Isoforms and DNA binding domain

Canis lupus familiaris

Synonyms: dog, dogs

Outlinks

Ensembl: ENSCAFG00000008104

Cavia porcellus

Synonyms: domestic guinea pig, guinea pig

Outlinks

Ensembl: ENSCPOG00000020975

Dasypus novemcinctus

Synonyms: nine-banded armadillo

Outlinks

Ensembl gene: ENSDNOG00000044362

Echinops telfairi

Synonyms: small Madagascar hedgehog, lesser hedgehog tenrec

Outlinks

Ensembl gene: ENSETEG00000007859
UniProt: NA

Felis catus

Synonyms: domestic cat, cats

Outlinks

Ensembl gene: ENSFCAG00000027132

Gorilla gorilla gorilla

Synonyms: western lowland gorilla, lowland gorilla

Outlinks

Ensembl gene: ENSGGOG00000008531

Homo sapiens

Synonyms: human, man

Outlinks

BioGPS: ENSG00000171056
Ensembl gene: ENSG00000171056
ProteinAtlas: ENSG00000171056 ( with antibody)
TRANSFAC: T06031
UniProt: Q9BT81

Protein expression pattern:Show tableIsoforms and DNA binding domain

Ictidomys tridecemlineatus

Synonyms: thirteen-lined ground squirrel

Outlinks

Ensembl gene: ENSSTOG00000025357
UniProt: NA

Loxodonta africana

Synonyms: African savanna elephant, African savannah elephant

Outlinks

Ensembl gene: ENSLAFG00000026855
UniProt: NA

Macaca mulatta

Synonyms: Rhesus monkey, rhesus monkeys

Outlinks

Ensembl gene: ENSMMUG00000010180

Macropus eugenii

Synonyms: tammar wallaby

Outlinks

Ensembl: ENSMEUG00000010385

Microcebus murinus

Synonyms: gray mouse lemur, grey mouse lemur

Outlinks

Ensembl gene: ENSMICG00000009404
UniProt: NA

Monodelphis domestica

Synonyms: gray short-tailed opossum

Outlinks

Ensembl gene: ENSMODG00000008896
UniProt: NA

Mus musculus

Synonyms: house mouse, mouse

Outlinks

Ensembl gene: ENSMUSG00000063060
TRANSFAC: T06032
UniProt: P40646

Isoforms and DNA binding domain

Mustela putorius furo

Synonyms: domestic ferret, ferret

Outlinks

Ensembl: ENSMPUG00000001773

Myotis lucifugus

Synonyms: little brown bat

Outlinks

Ensembl gene: ENSMLUG00000029313
UniProt: NA

Nomascus leucogenys

Synonyms: northern white-cheeked gibbon, White-cheeked Gibbon

Outlinks

Ensembl gene: ENSNLEG00000015013
UniProt: NA

Ochotona princeps

Synonyms: American pika, southern American pika

Outlinks

Ensembl gene: ENSOPRG00000004437
UniProt: NA

Oryctolagus cuniculus

Synonyms: rabbit, rabbits

Outlinks

Ensembl gene: ENSOCUG00000000468

Otolemur garnettii

Synonyms: small-eared galago

Outlinks

Ensembl gene: ENSOGAG00000034608

Pan troglodytes

Synonyms: chimpanzee

Outlinks

Ensembl gene: ENSPTRG00000028919

Pteropus vampyrus

Synonyms: large flying fox

Outlinks

Ensembl gene: ENSPVAG00000010439
UniProt: NA

Rattus norvegicus

Synonyms: Norway rat, rats

Outlinks

Ensembl gene: ENSRNOG00000012049
UniProt: D3ZTE1

Isoforms and DNA binding domain

Sarcophilus harrisii

Synonyms: Tasmanian devil

Outlinks

Ensembl gene: ENSSHAG00000010182
UniProt: NA

Sus scrofa

Synonyms: pig, wild boar

Outlinks

Ensembl: ENSSSCG00000027044

Tupaia belangeri

Synonyms: northern tree shrew, common tree shrew

Outlinks

Ensembl gene: ENSTBEG00000003228
UniProt: NA

Select species

Selected the species for which a species report should be shown.

Ailuropoda melanoleuca, giant panda
Bos taurus, cattle
Callithrix jacchus, white-tufted-ear marmoset
Canis lupus familiaris, dog
Cavia porcellus, domestic guinea pig
Choloepus hoffmanni, Hoffmann's two-fingered sloth
Dasypus novemcinctus, nine-banded armadillo
Dipodomys ordii, Ord's kangaroo rat
Echinops telfairi, small Madagascar hedgehog
Equus caballus, horse
Erinaceus europaeus, western European hedgehog
Felis catus, domestic cat
Gorilla gorilla gorilla, western lowland gorilla
Homo sapiens, human
Ictidomys tridecemlineatus, thirteen-lined ground squirrel
Loxodonta africana, African savanna elephant
Macaca mulatta, Rhesus monkey
Macropus eugenii, tammar wallaby
Microcebus murinus, gray mouse lemur
Monodelphis domestica, gray short-tailed opossum
Mus musculus, house mouse
Mustela putorius furo, domestic ferret
Myotis lucifugus, little brown bat
Nomascus leucogenys, northern white-cheeked gibbon
Ochotona princeps, American pika
Ornithorhynchus anatinus, platypus
Oryctolagus cuniculus, rabbit
Otolemur garnettii, small-eared galago
Ovis aries, sheep
Pan troglodytes, chimpanzee
Pongo abelii, Sumatran orangutan
Procavia capensis, Cape rock hyrax
Pteropus vampyrus, large flying fox
Rattus norvegicus, Norway rat
Sarcophilus harrisii, Tasmanian devil
Sorex araneus, European shrew
Sus scrofa, pig
Tarsius syrichta, Philippine tarsier
Tupaia belangeri, northern tree shrew
Tursiops truncatus, bottlenose dolphin
Vicugna pacos, alpaca

Expression table

The table below summarizes the protein expression data from the Protein Atlas. The tissues and cell types are linked to the Cytomer ontology

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Tissue	Cell type	Expression level	Type	Reliability
adrenal gland	glandular tissue	Moderate	Staining	Supportive
appendix	glandular tissue	Weak	Staining	Supportive
appendix	lymphoid tissue	Negative	Staining	Supportive
bone barrow	hematopoetic stem cell	Weak	Staining	Supportive
breast	glandular tissue	Weak	Staining	Supportive
bronchi	ciliated call with propulsive function of respiratory tract	Moderate	Staining	Supportive
cerebellum	granule cell	Negative	Staining	Supportive
cerebellum		Negative	Staining	Supportive
cerebellum	purkinje cell	Weak	Staining	Supportive
cerebral cortex	glial cell of central nervous system	Weak	Staining	Supportive
cerebral cortex	neuron	Moderate	Staining	Supportive
cervix of uterus	glandular tissue	Moderate	Staining	Supportive
cervix of uterus	squamous epithelial cell	Moderate	Staining	Supportive
colon	glandular tissue	Moderate	Staining	Supportive
duodenum	glandular tissue	Moderate	Staining	Supportive

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