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Classification of Transcription Factors in Mammalia

About TFClass

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Family:

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1 Basic domains
- 1.1 Basic leucine zipper factors (bZIP)
- 1.2 Basic helix-loop-helix factors (bHLH)
  - 1.2.1 E2A
  - 1.2.2 MyoD-ASC-related
  - 1.2.3 Tal-related
  - 1.2.4 Hairy-related
    - 1.2.4.1 HAIRY
      - 1.2.4.1.1 HES1
      - 1.2.4.1.2 HES2
      - 1.2.4.1.3 HES3
      - 1.2.4.1.4 HES4
      - 1.2.4.1.5 HES5
      - 1.2.4.1.6 HES6
      - 1.2.4.1.7 HES7
      - 1.2.4.1.8 HEY1
      - 1.2.4.1.9 HEY2
      - 1.2.4.1.10 HEYL
      - 1.2.4.1.11 HELT
      - 1.2.4.1.12 DEC1/BHLHE40
      - 1.2.4.1.13 DEC2/BHLHE41
  - 1.2.5 PAS
  - 1.2.6 bHLH-ZIP
  - 1.2.8 HLH only
- 1.3 Basic helix-span-helix factors (bHSH)
2 Zinc-coordinating DNA-binding domains
3 Helix-turn-helix domains
4 Other all-alpha-helical DNA-binding domains
5 alpha-Helices exposed by beta-structures
6 Immunoglobulin fold
7 beta-Hairpin exposed by an alpha/beta-scaffold
8 beta-Sheet binding to DNA
9 beta-Barrel DNA-binding domains
0 Yet undefined DNA-binding domains

General

Species within this Genus: 29 LOGO plot of the DNA binding sequence

Species specific reports

Jump to human, mouse or rat
Hint: You can rearrange the panels by drag-and-drop. The new arrangement will persist during your session.

Ailuropoda melanoleuca

Synonyms: giant panda

Outlinks

Ensembl gene: ENSAMEG00000016060

Bos taurus

Synonyms: cattle, domestic cow

Outlinks

Ensembl gene: ENSBTAG00000009863
UniProt: Q5EA15

Isoforms and DNA binding domain

Callithrix jacchus

Synonyms: white-tufted-ear marmoset, white ear-tufted marmoset

Outlinks

Ensembl gene: ENSCJAG00000015832
UniProt: F7I5L6

Isoforms and DNA binding domain

Canis lupus familiaris

Synonyms: dog, dogs

Outlinks

Ensembl: ENSCAFG00000005621

Cavia porcellus

Synonyms: domestic guinea pig, guinea pig

Outlinks

Ensembl gene: ENSCPOG00000004014

Dasypus novemcinctus

Synonyms: nine-banded armadillo

Outlinks

Ensembl gene: ENSDNOG00000035717

Dipodomys ordii

Synonyms: Ord's kangaroo rat

Outlinks

Ensembl: ENSDORG00000006908

Equus caballus

Synonyms: horse, equine

Outlinks

Ensembl gene: ENSECAG00000015069

Felis catus

Synonyms: domestic cat, cats

Outlinks

Ensembl gene: ENSFCAG00000002966

Homo sapiens

Synonyms: human, man

Outlinks

BioGPS: ENSG00000173077
Ensembl: ENSGGOG00000015864
Ensembl: ENSPTRG00000014571
Ensembl gene: ENSG00000134107
ProteinAtlas: ENSG00000173077 ( without antibody)
TRANSFAC: T05838
UniProt: O14503

Protein expression pattern:Show tableIsoforms and DNA binding domain

Ictidomys tridecemlineatus

Synonyms: thirteen-lined ground squirrel

Outlinks

Ensembl gene: ENSSTOG00000000793
UniProt: NA

Loxodonta africana

Synonyms: African savanna elephant, African savannah elephant

Outlinks

Ensembl gene: ENSLAFG00000004896
UniProt: NA

Macaca mulatta

Synonyms: Rhesus monkey, rhesus monkeys

Outlinks

Ensembl: ENSMMUG00000014588

Macropus eugenii

Synonyms: tammar wallaby

Outlinks

Ensembl: ENSMEUG00000010801

Microcebus murinus

Synonyms: gray mouse lemur, grey mouse lemur

Outlinks

Ensembl: ENSMICG00000011495

Monodelphis domestica

Synonyms: gray short-tailed opossum

Outlinks

Ensembl gene: ENSMODG00000004516
UniProt: NA

Mus musculus

Synonyms: house mouse, mouse

Outlinks

Ensembl gene: ENSMUSG00000030103
TRANSFAC: T02327
UniProt: O35185

Isoforms and DNA binding domain

Mustela putorius furo

Synonyms: domestic ferret, ferret

Outlinks

Ensembl: ENSMPUG00000017029

Nomascus leucogenys

Synonyms: northern white-cheeked gibbon, White-cheeked Gibbon

Outlinks

Ensembl gene: ENSNLEG00000003704
Ensembl gene: ENSNLEG00000026535
UniProt: NA

Ornithorhynchus anatinus

Synonyms: platypus, duckbill platypus

Outlinks

Ensembl gene: ENSOANG00000003764
UniProt: NA

Oryctolagus cuniculus

Synonyms: rabbit, rabbits

Outlinks

Ensembl gene: ENSOCUG00000015177

Otolemur garnettii

Synonyms: small-eared galago

Outlinks

Ensembl gene: ENSOGAG00000029762

Ovis aries

Synonyms: sheep, wild sheep

Outlinks

Ensembl gene: ENSOARG00000007840

Pongo abelii

Synonyms: Sumatran orangutan, orang utan

Outlinks

Ensembl gene: ENSPPYG00000013696

Pteropus vampyrus

Synonyms: large flying fox

Outlinks

Ensembl gene: ENSPVAG00000007723
UniProt: NA

Rattus norvegicus

Synonyms: Norway rat, rats

Outlinks

Ensembl gene: ENSRNOG00000007152
UniProt: Q76JQ4

Isoforms and DNA binding domain

Sus scrofa

Synonyms: pig, wild boar

Outlinks

Ensembl: ENSSSCG00000011534

Tarsius syrichta

Synonyms: Philippine tarsier

Outlinks

Ensembl: ENSTSYG00000002535

Tursiops truncatus

Synonyms: bottlenose dolphin, bottle-nosed dolphin

Outlinks

Ensembl gene: ENSTTRG00000002786
UniProt: NA

Select species

Selected the species for which a species report should be shown.

Ailuropoda melanoleuca, giant panda
Bos taurus, cattle
Callithrix jacchus, white-tufted-ear marmoset
Canis lupus familiaris, dog
Cavia porcellus, domestic guinea pig
Choloepus hoffmanni, Hoffmann's two-fingered sloth
Dasypus novemcinctus, nine-banded armadillo
Dipodomys ordii, Ord's kangaroo rat
Echinops telfairi, small Madagascar hedgehog
Equus caballus, horse
Erinaceus europaeus, western European hedgehog
Felis catus, domestic cat
Gorilla gorilla gorilla, western lowland gorilla
Homo sapiens, human
Ictidomys tridecemlineatus, thirteen-lined ground squirrel
Loxodonta africana, African savanna elephant
Macaca mulatta, Rhesus monkey
Macropus eugenii, tammar wallaby
Microcebus murinus, gray mouse lemur
Monodelphis domestica, gray short-tailed opossum
Mus musculus, house mouse
Mustela putorius furo, domestic ferret
Myotis lucifugus, little brown bat
Nomascus leucogenys, northern white-cheeked gibbon
Ochotona princeps, American pika
Ornithorhynchus anatinus, platypus
Oryctolagus cuniculus, rabbit
Otolemur garnettii, small-eared galago
Ovis aries, sheep
Pan troglodytes, chimpanzee
Pongo abelii, Sumatran orangutan
Procavia capensis, Cape rock hyrax
Pteropus vampyrus, large flying fox
Rattus norvegicus, Norway rat
Sarcophilus harrisii, Tasmanian devil
Sorex araneus, European shrew
Sus scrofa, pig
Tarsius syrichta, Philippine tarsier
Tupaia belangeri, northern tree shrew
Tursiops truncatus, bottlenose dolphin
Vicugna pacos, alpaca

Expression table

The table below summarizes the protein expression data from the Protein Atlas. The tissues and cell types are linked to the Cytomer ontology

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Tissue	Cell type	Expression level	Type	Reliability
adrenal gland	glandular tissue	Moderate	Staining	Uncertain
appendix	glandular tissue	Moderate	Staining	Uncertain
appendix	lymphoid tissue	Weak	Staining	Uncertain
bone barrow	hematopoetic stem cell	Strong	Staining	Uncertain
breast	glandular tissue	Moderate	Staining	Uncertain
bronchi	ciliated call with propulsive function of respiratory tract	Moderate	Staining	Uncertain
cerebellum	granule cell	Weak	Staining	Uncertain
cerebellum		Moderate	Staining	Uncertain
cerebellum	purkinje cell	Moderate	Staining	Uncertain
cerebral cortex	glial cell of central nervous system	Negative	Staining	Uncertain
cerebral cortex	neuron	Strong	Staining	Uncertain
cervix of uterus	squamous epithelial cell	Moderate	Staining	Uncertain
colon	glandular tissue	Moderate	Staining	Uncertain
duodenum	glandular tissue	Moderate	Staining	Uncertain
epididymis	glandular tissue	Strong	Staining	Uncertain

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