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Classification of Transcription Factors in Mammalia

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Family:

, Subfamily:

, Genus:

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1 Basic domains
2 Zinc-coordinating DNA-binding domains
3 Helix-turn-helix domains
- 3.1 Homeo domain factors
  - 3.1.1 HOX
  - 3.1.2 NK
  - 3.1.3 Paired-related HD
    - 3.1.3.1 ALX
    - 3.1.3.2 ARGFX
    - 3.1.3.3 ARX
    - 3.1.3.4 DMBX
    - 3.1.3.5 DPRX
    - 3.1.3.6 DRGX
    - 3.1.3.7 DUX
    - 3.1.3.8 ESX
    - 3.1.3.9 GSC
      - 3.1.3.9.1 GSC
      - 3.1.3.9.2 GSC2
    - 3.1.3.10 HESX
    - 3.1.3.11 HOPX
    - 3.1.3.12 ISX
    - 3.1.3.13 LEUTX
    - 3.1.3.14 MIX
    - 3.1.3.15 NOBOX
    - 3.1.3.16 OTP
    - 3.1.3.17 OTX
    - 3.1.3.18 PHOX
    - 3.1.3.19 PITX
    - 3.1.3.20 PROP
    - 3.1.3.21 PRRX
    - 3.1.3.22 RAX
    - 3.1.3.23 RHOX
    - 3.1.3.24 SEBOX
    - 3.1.3.25 SHOX
    - 3.1.3.26 TPRX
    - 3.1.3.27 UNCX
    - 3.1.3.28 VSX
  - 3.1.4 TALE-type HD
  - 3.1.5 HD-LIM
  - 3.1.6 HD-SINE
  - 3.1.7 HD-PROS
  - 3.1.8 HD-ZF
  - 3.1.9 HD-CUT
  - 3.1.10 POU
  - 3.1.11 PHTF
- 3.2 Paired box factors
- 3.3 Fork head / winged helix factors
- 3.4 Heat shock factors
- 3.5 Tryptophan cluster factors
- 3.6 TEA domain factors
- 3.7 ARID
4 Other all-alpha-helical DNA-binding domains
5 alpha-Helices exposed by beta-structures
6 Immunoglobulin fold
7 beta-Hairpin exposed by an alpha/beta-scaffold
8 beta-Sheet binding to DNA
9 beta-Barrel DNA-binding domains
0 Yet undefined DNA-binding domains

General

Species within this Genus: 21 LOGO plot of the DNA binding sequence

Species specific reports

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Bos taurus

Synonyms: cattle, domestic cow

Outlinks

Ensembl gene: ENSBTAG00000047526

Callithrix jacchus

Synonyms: white-tufted-ear marmoset, white ear-tufted marmoset

Outlinks

Ensembl gene: ENSCJAG00000001670

Cavia porcellus

Synonyms: domestic guinea pig, guinea pig

Outlinks

Ensembl gene: ENSCPOG00000015708

Dasypus novemcinctus

Synonyms: nine-banded armadillo

Outlinks

Ensembl gene: ENSDNOG00000012746

Dipodomys ordii

Synonyms: Ord's kangaroo rat

Outlinks

Ensembl gene: ENSDORG00000003785
UniProt: NA

Erinaceus europaeus

Synonyms: western European hedgehog, common hedgehog

Outlinks

Ensembl gene: ENSEEUG00000003981
UniProt: NA

Gorilla gorilla gorilla

Synonyms: western lowland gorilla, lowland gorilla

Outlinks

Ensembl gene: ENSGGOG00000022383

Homo sapiens

Synonyms: human, man

Outlinks

BioGPS: ENSG00000063515
Ensembl gene: ENSG00000063515
ProteinAtlas: ENSG00000063515 ( with antibody)
TRANSFAC: T04038
UniProt: O15499

Protein expression pattern:Show tableIsoforms and DNA binding domain

Ictidomys tridecemlineatus

Synonyms: thirteen-lined ground squirrel

Outlinks

Ensembl gene: ENSSTOG00000021301
UniProt: NA

Loxodonta africana

Synonyms: African savanna elephant, African savannah elephant

Outlinks

Ensembl gene: ENSLAFG00000000420
UniProt: NA

Macaca mulatta

Synonyms: Rhesus monkey, rhesus monkeys

Outlinks

Ensembl gene: ENSMMUG00000020988

Macropus eugenii

Synonyms: tammar wallaby

Outlinks

Ensembl: ENSMEUG00000007971

Mus musculus

Synonyms: house mouse, mouse

Outlinks

Ensembl gene: ENSMUSG00000022738
TRANSFAC: T04039
UniProt: A2RTU1

Isoforms and DNA binding domain

Ochotona princeps

Synonyms: American pika, southern American pika

Outlinks

Ensembl gene: ENSOPRG00000011642
UniProt: NA

Ornithorhynchus anatinus

Synonyms: platypus, duckbill platypus

Outlinks

Ensembl gene: ENSOANG00000012938
UniProt: NA

Otolemur garnettii

Synonyms: small-eared galago

Outlinks

Ensembl gene: ENSOGAG00000029019

Pongo abelii

Synonyms: Sumatran orangutan, orang utan

Outlinks

Ensembl gene: ENSPPYG00000011575

Pteropus vampyrus

Synonyms: large flying fox

Outlinks

Ensembl gene: ENSPVAG00000001660
UniProt: NA

Rattus norvegicus

Synonyms: Norway rat, rats

Outlinks

Ensembl gene: ENSRNOG00000000282
UniProt: D3Z9R9

Isoforms and DNA binding domain

Sarcophilus harrisii

Synonyms: Tasmanian devil

Outlinks

Ensembl gene: ENSSHAG00000008223
UniProt: NA

Sus scrofa

Synonyms: pig, wild boar

Outlinks

Ensembl gene: ENSSSCG00000010115

Select species

Selected the species for which a species report should be shown.

Ailuropoda melanoleuca, giant panda
Bos taurus, cattle
Callithrix jacchus, white-tufted-ear marmoset
Canis lupus familiaris, dog
Cavia porcellus, domestic guinea pig
Choloepus hoffmanni, Hoffmann's two-fingered sloth
Dasypus novemcinctus, nine-banded armadillo
Dipodomys ordii, Ord's kangaroo rat
Echinops telfairi, small Madagascar hedgehog
Equus caballus, horse
Erinaceus europaeus, western European hedgehog
Felis catus, domestic cat
Gorilla gorilla gorilla, western lowland gorilla
Homo sapiens, human
Ictidomys tridecemlineatus, thirteen-lined ground squirrel
Loxodonta africana, African savanna elephant
Macaca mulatta, Rhesus monkey
Macropus eugenii, tammar wallaby
Microcebus murinus, gray mouse lemur
Monodelphis domestica, gray short-tailed opossum
Mus musculus, house mouse
Mustela putorius furo, domestic ferret
Myotis lucifugus, little brown bat
Nomascus leucogenys, northern white-cheeked gibbon
Ochotona princeps, American pika
Ornithorhynchus anatinus, platypus
Oryctolagus cuniculus, rabbit
Otolemur garnettii, small-eared galago
Ovis aries, sheep
Pan troglodytes, chimpanzee
Pongo abelii, Sumatran orangutan
Procavia capensis, Cape rock hyrax
Pteropus vampyrus, large flying fox
Rattus norvegicus, Norway rat
Sarcophilus harrisii, Tasmanian devil
Sorex araneus, European shrew
Sus scrofa, pig
Tarsius syrichta, Philippine tarsier
Tupaia belangeri, northern tree shrew
Tursiops truncatus, bottlenose dolphin
Vicugna pacos, alpaca

Expression table

The table below summarizes the protein expression data from the Protein Atlas. The tissues and cell types are linked to the Cytomer ontology

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Tissue	Cell type	Expression level	Type	Reliability
adrenal gland	glandular tissue	Strong	Staining	Uncertain
appendix	glandular tissue	Moderate	Staining	Uncertain
appendix	lymphoid tissue	Moderate	Staining	Uncertain
bone barrow	hematopoetic stem cell	Negative	Staining	Uncertain
breast	glandular tissue	Strong	Staining	Uncertain
bronchi	ciliated call with propulsive function of respiratory tract	Strong	Staining	Uncertain
cerebellum	granule cell	Negative	Staining	Uncertain
cerebellum		Negative	Staining	Uncertain
cerebellum	purkinje cell	Moderate	Staining	Uncertain
cerebral cortex	glial cell of central nervous system	Weak	Staining	Uncertain
cerebral cortex	neuron	Weak	Staining	Uncertain
cervix of uterus	glandular tissue	Moderate	Staining	Uncertain
cervix of uterus	squamous epithelial cell	Strong	Staining	Uncertain
colon	glandular tissue	Moderate	Staining	Uncertain
duodenum	glandular tissue	Moderate	Staining	Uncertain

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