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Classification of Transcription Factors in Mammalia

About TFClass

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Superclass:

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Family:

, Subfamily:

, Genus:

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1 Basic domains
2 Zinc-coordinating DNA-binding domains
3 Helix-turn-helix domains
4 Other all-alpha-helical DNA-binding domains
5 alpha-Helices exposed by beta-structures
6 Immunoglobulin fold
7 beta-Hairpin exposed by an alpha/beta-scaffold
- 7.1 SMAD/NF-1 DNA-binding domain factors
  - 7.1.1 SMAD
    - 7.1.1.1 R-MAD
    - 7.1.1.2 Co-SMAD
      - 7.1.1.2.1 SMAD4
    - 7.1.1.3 I-SMAD
  - 7.1.2 NF-1
- 7.2 GCM domain factors
8 beta-Sheet binding to DNA
9 beta-Barrel DNA-binding domains
0 Yet undefined DNA-binding domains

General

Species within this Genus: 34

Species specific reports

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Ailuropoda melanoleuca

Synonyms: giant panda

Outlinks

Ensembl gene: ENSAMEG00000002899
UniProt: D2H520

Isoforms and DNA binding domain

Bos taurus

Synonyms: cattle, domestic cow

Outlinks

Ensembl gene: ENSBTAG00000006919
UniProt: B0JYL0

Isoforms and DNA binding domain

Callithrix jacchus

Synonyms: white-tufted-ear marmoset, white ear-tufted marmoset

Outlinks

Ensembl gene: ENSCJAG00000001910
UniProt: F7GUQ9

Isoforms and DNA binding domain

Canis lupus familiaris

Synonyms: dog, dogs

Outlinks

Ensembl: ENSCAFG00000000164

Cavia porcellus

Synonyms: domestic guinea pig, guinea pig

Outlinks

Ensembl gene: ENSCPOG00000006470

Choloepus hoffmanni

Synonyms: Hoffmann's two-fingered sloth, Hoffmann's two-toed sloth

Outlinks

Ensembl gene: ENSCHOG00000000860
UniProt: NA

Dasypus novemcinctus

Synonyms: nine-banded armadillo

Outlinks

Ensembl gene: ENSDNOG00000005063

Echinops telfairi

Synonyms: small Madagascar hedgehog, lesser hedgehog tenrec

Outlinks

Ensembl gene: ENSETEG00000007750
UniProt: NA

Equus caballus

Synonyms: horse, equine

Outlinks

Ensembl gene: ENSECAG00000017857

Felis catus

Synonyms: domestic cat, cats

Outlinks

Ensembl gene: ENSFCAG00000005257

Gorilla gorilla gorilla

Synonyms: western lowland gorilla, lowland gorilla

Outlinks

Ensembl gene: ENSGGOG00000013662

Homo sapiens

Synonyms: human, man

Outlinks

BioGPS: ENSG00000141646
Ensembl gene: ENSG00000141646
ProteinAtlas: ENSG00000141646 ( with antibody)
TRANSFAC: T04292
UniProt: Q13485

Protein expression pattern:Show tableIsoforms and DNA binding domain

Ictidomys tridecemlineatus

Synonyms: thirteen-lined ground squirrel

Outlinks

Ensembl gene: ENSSTOG00000028580
UniProt: NA

Loxodonta africana

Synonyms: African savanna elephant, African savannah elephant

Outlinks

Ensembl gene: ENSLAFG00000012595
UniProt: NA

Macaca mulatta

Synonyms: Rhesus monkey, rhesus monkeys

Outlinks

Ensembl gene: ENSMMUG00000018334
UniProt: F7H894

Isoforms and DNA binding domain

Monodelphis domestica

Synonyms: gray short-tailed opossum

Outlinks

Ensembl gene: ENSMODG00000010995
UniProt: NA

Mus musculus

Synonyms: house mouse, mouse

Outlinks

Ensembl gene: ENSMUSG00000024515
TRANSFAC: T05067
UniProt: P97471

Isoforms and DNA binding domain

Mustela putorius furo

Synonyms: domestic ferret, ferret

Outlinks

Ensembl: ENSMPUG00000008776

Myotis lucifugus

Synonyms: little brown bat

Outlinks

Ensembl gene: ENSMLUG00000013944
UniProt: NA

Nomascus leucogenys

Synonyms: northern white-cheeked gibbon, White-cheeked Gibbon

Outlinks

Ensembl gene: ENSNLEG00000011859
UniProt: NA

Ochotona princeps

Synonyms: American pika, southern American pika

Outlinks

Ensembl gene: ENSOPRG00000013601
UniProt: NA

Ornithorhynchus anatinus

Synonyms: platypus, duckbill platypus

Outlinks

Ensembl gene: ENSOANG00000008117
UniProt: NA

Oryctolagus cuniculus

Synonyms: rabbit, rabbits

Outlinks

Ensembl gene: ENSOCUG00000003929

Otolemur garnettii

Synonyms: small-eared galago

Outlinks

Ensembl gene: ENSOGAG00000012081

Ovis aries

Synonyms: sheep, wild sheep

Outlinks

Ensembl gene: ENSOARG00000004662

Pan troglodytes

Synonyms: chimpanzee

Outlinks

Ensembl gene: ENSPTRG00000010028
UniProt: H2QEJ6

Isoforms and DNA binding domain

Pongo abelii

Synonyms: Sumatran orangutan, orang utan

Outlinks

Ensembl gene: ENSPPYG00000009165

Rattus norvegicus

Synonyms: Norway rat, rats

Outlinks

Ensembl: ENSRNOG00000015634

Sarcophilus harrisii

Synonyms: Tasmanian devil

Outlinks

Ensembl gene: ENSSHAG00000010344
UniProt: NA

Sorex araneus

Synonyms: European shrew, Eurasian shrew

Outlinks

Ensembl gene: ENSSARG00000013883
UniProt: NA

Sus scrofa

Synonyms: pig, wild boar

Outlinks

Ensembl gene: ENSSSCG00000004524
UniProt: Q9GKQ9

Isoforms and DNA binding domain

Tarsius syrichta

Synonyms: Philippine tarsier

Outlinks

Ensembl: ENSTSYG00000009792

Tursiops truncatus

Synonyms: bottlenose dolphin, bottle-nosed dolphin

Outlinks

Ensembl gene: ENSTTRG00000011767
UniProt: NA

Vicugna pacos

Synonyms: alpaca

Outlinks

Ensembl gene: ENSVPAG00000006757
UniProt: NA

Select species

Selected the species for which a species report should be shown.

Ailuropoda melanoleuca, giant panda
Bos taurus, cattle
Callithrix jacchus, white-tufted-ear marmoset
Canis lupus familiaris, dog
Cavia porcellus, domestic guinea pig
Choloepus hoffmanni, Hoffmann's two-fingered sloth
Dasypus novemcinctus, nine-banded armadillo
Dipodomys ordii, Ord's kangaroo rat
Echinops telfairi, small Madagascar hedgehog
Equus caballus, horse
Erinaceus europaeus, western European hedgehog
Felis catus, domestic cat
Gorilla gorilla gorilla, western lowland gorilla
Homo sapiens, human
Ictidomys tridecemlineatus, thirteen-lined ground squirrel
Loxodonta africana, African savanna elephant
Macaca mulatta, Rhesus monkey
Macropus eugenii, tammar wallaby
Microcebus murinus, gray mouse lemur
Monodelphis domestica, gray short-tailed opossum
Mus musculus, house mouse
Mustela putorius furo, domestic ferret
Myotis lucifugus, little brown bat
Nomascus leucogenys, northern white-cheeked gibbon
Ochotona princeps, American pika
Ornithorhynchus anatinus, platypus
Oryctolagus cuniculus, rabbit
Otolemur garnettii, small-eared galago
Ovis aries, sheep
Pan troglodytes, chimpanzee
Pongo abelii, Sumatran orangutan
Procavia capensis, Cape rock hyrax
Pteropus vampyrus, large flying fox
Rattus norvegicus, Norway rat
Sarcophilus harrisii, Tasmanian devil
Sorex araneus, European shrew
Sus scrofa, pig
Tarsius syrichta, Philippine tarsier
Tupaia belangeri, northern tree shrew
Tursiops truncatus, bottlenose dolphin
Vicugna pacos, alpaca

Expression table

The table below summarizes the protein expression data from the Protein Atlas. The tissues and cell types are linked to the Cytomer ontology

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Tissue	Cell type	Expression level	Type	Reliability
adrenal gland	glandular tissue	Medium	APE	Medium
appendix	glandular tissue	High	APE	Medium
appendix	lymphoid tissue	Medium	APE	Medium
bone barrow	hematopoetic stem cell	High	APE	Medium
breast	glandular tissue	Medium	APE	Medium
bronchi	ciliated call with propulsive function of respiratory tract	Medium	APE	Medium
cerebellum	granule cell	Low	APE	Medium
cerebellum		None	APE	Medium
cerebellum	purkinje cell	None	APE	Medium
cerebral cortex	glial cell of central nervous system	None	APE	Medium
cerebral cortex	neuron	Low	APE	Medium
cervix of uterus	glandular tissue	Medium	APE	Medium
cervix of uterus	squamous epithelial cell	None	APE	Medium
colon	glandular tissue	High	APE	Medium
duodenum	glandular tissue	High	APE	Medium

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