About SMAD/NF-1 DNA-binding domain factorsTRANSFAC
® class description C0059: Significant similarities between DNA binding domains of Smad and NF1 factors have been revealed by a PSI-BLAST database search. Authors have proposed that Smad and NF1 factors belong to the same group of genes probably resulting from the common ancestry [25470]. For more details about Smad or NF1 factors see
and correspondingly. TRANSFAC class description C0041: Proteins with 2 MAD-homology domains at N- and C-terminal ends, which have been named MH1 and MH2, are independently folded structures (PMID 10605817); the structure of the MH2 domain is a beta-sandwich with a 3-alpha-helix bundle at one end, and 3 large loops and an alpha-helix at the other end (PMID 10605817); the loop-helix region of one subunit packs against the 3-alpha-helix bundle of another subunit (PMID 10605817); MH1, a novel type of DBD, consists of 4 alpha-helixes, 6 short beta-strands, and 5 loops. Beta-strands form 2 small beta-sheets and 1 beta-hairpin (PMID 9741623); base-specific DNA recognition of the MH1 domain bound to a GTCT motif is via an 11-amino acid beta-hairpin, which lies in the major groove of the DNA (PMID 9741623, PMID 10605817); 3 classes of SMAD: Inhibitory SMADs (SMAD-6,SMAD-7), Receptor-regulated SMADs (SMAD-1, SMAD-2, SMAD-3, SMAD-5, SMAD-8), Common Mediator SMADs (SMAD-4, SMAD-4beta, SMAD-10). (PMID 10605817) More informationSpecies within this Class: 41
Genera within this Class: 12
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DNA binding domain |
Whole protein |
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FASTA file |
Phylogenetic tree
Mammalia
These trees (or cladograms, since distances were ignored) were generated with a local installation of PhyML 3.0 (Guindon et al., Systematic Biology, 59(3):307-21, 2010.), by webPRANK at EBI (http://www.ebi.ac.uk/goldman-srv/webprank/), or by the web version of PhyML 3.0 (http://phylogeny.lirmm.fr). The resulting trees were visualized with iTOL v3 (http://itol.embl.de/).
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Phylogenetic tree Mammalia
(slim selection)
To generate these trees, only the TFs were taken from a selected group of mammalian species. As standard, the corresponding human, cow, mouse and Monodelphis TFs were taken if available; occasionally, either species was to replaced or had to be omitted without replacement.
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