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Classification of Transcription Factors in Mammalia

About TFClass

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Family: , Subfamily: , Genus: ,
  • 6 Immunoglobulin fold
About T-Box factors
TRANSFAC® class description C0044: The T domain has originally been discovered in Brachyury (T) the founder member of the T-box family. It encodes a DNA binding domain of about 180 amino acids. X-ray analysis of the T domain showed that it binds as a dimer to a 20 nucleotide partially palindromic sequence. A new type of specific DNA contact is seen, in which a carboxy-terminal helix is deeply embedded into an enlarged minor groove without bending the DNA. More informationSpecies within this Class: 41 Genera within this Class: 15 LOGO plot of the DNA binding domain
FASTA file of the LogoPlot
DNA binding domain Whole protein
Phylogenetic tree
These trees (or cladograms, since distances were ignored) were generated with a local installation of PhyML 3.0 (Guindon et al., Systematic Biology, 59(3):307-21, 2010.), by webPRANK at EBI (, or by the web version of PhyML 3.0 ( The resulting trees were visualized with iTOL v3 (
    • and iTOL
    Phylogenetic tree Mammalia
    (slim selection)
    To generate these trees, only the TFs were taken from a selected group of mammalian species. As standard, the corresponding human, cow, mouse and Monodelphis TFs were taken if available; occasionally, either species was to replaced or had to be omitted without replacement.
    • webPRANK and iTOL
    • and iTOL
    • and iTOL
    • webPRANK and iTOL
    Select species

    Selected the species for which a species report should be shown.

    Expression table
    The table below summarizes the protein expression data from the Protein Atlas. The tissues and cell types are linked to the Cytomer ontology

    The selected tree node is not linked to a gene, no expression data is available.