About STAT domain factorsClass description: STAT proteins bind to DNA as dimers. The DNA-contacting interface is organized by an eight-stranded beta-barrel, N-terminally preceded by a four-helix bundle and C-terminally followed by a mostly alpha-helical connector region. The residues that bind to the major groove of the DNA are mostly exposed by loops connecting the beta-strands of the beta-barrel and the one linking the beta-barrel and the first helix of the 'connector' region. The STAT dimer nearly completely embraces the DNA double helix, compared with a 'pair of pliers' (PMID 9671298), with the DNA-binding interface as jaws and the four-helix bundles as handles. Bound by STAT, the DNA undergoes a moderate bending of about 40 degrees. (PMID 9671298)
More informationSpecies within this Class: 34
Genera within this Class: 7
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DNA binding domain |
Whole protein |
| FASTA |
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