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Classification of Transcription Factors in Mammalia

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  • 6 Immunoglobulin fold
About Rel homology region (RHR) factors
TRANSFAC® class description C0020: The structure of the Rel-type DBD exhibits a bipartite subdomain structure, each subdomain comprising a beta-barrel with five loops that form an extensive contact surface to the major groove of the DNA. Particularly, the first loop of the N-terminal subdomain (the highly conserved recognition loop) performs contacts with the recognition element on the DNA, but other loops are involved. The fact that the main DNA-contacts are made through loops has been suggested to provide a high degree of flexibility in binding to a range of different target sequences. Augmenting interactions are achieved by two alpha-helices within the N-terminal part that form strong minor groove contacts to the A/T-rich center of the B-element. In p65, the sequence between both alpha-helices is much shorter and even helix 2 is truncated. The second, C-terminal domain is necessary mainly for protein dimerization. More informationSpecies within this Class: 39 Genera within this Class: 18 LOGO plot of the DNA binding domain
FASTA file of the LogoPlot
DNA binding domain Whole protein
Phylogenetic tree Mammalia
(slim selection)
To generate these trees, only the TFs were taken from a selected group of mammalian species. As standard, the corresponding human, cow, mouse and Monodelphis TFs were taken if available; occasionally, either species was to replaced or had to be omitted without replacement.
  • webPRANK and iTOL
  • and iTOL
  • webPRANK and iTOL
  • and iTOL
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Selected the species for which a species report should be shown.

Expression table
The table below summarizes the protein expression data from the Protein Atlas. The tissues and cell types are linked to the Cytomer ontology

The selected tree node is not linked to a gene, no expression data is available.