About MADS box factorsTRANSFAC
® class description C0014: Proteins of this class comprise a region of homology. The DNA-binding domain also comprises the dimerization capability. In the DNA-bound dimer (shown for SRF), two antiparallel amphipathic alpha-helices (alpha-I), form a coiled coil and are oriented approximately parallel on the minor groove. These helices make minor and major groove contacts, the N-terminal extensions form minor groove contacts. The bound DNA is bent and wrapped around the protein. It exhibits a compressed minor groove in the center and widened minor groove in the flanks. (PMID 7637780)
More informationSpecies within this Class: 38
Genera within this Class: 5
LOGO plot of the DNA binding domain
FASTA file of the LogoPlot
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DNA binding domain |
Whole protein |
| FASTA |
FASTA file |
FASTA file |
Phylogenetic tree
Mammalia
These trees (or cladograms, since distances were ignored) were generated with a local installation of PhyML 3.0 (Guindon et al., Systematic Biology, 59(3):307-21, 2010.), by webPRANK at EBI (http://www.ebi.ac.uk/goldman-srv/webprank/), or by the web version of PhyML 3.0 (http://phylogeny.lirmm.fr). The resulting trees were visualized with iTOL v3 (http://itol.embl.de/).
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