About C2CH THAP-type zinc finger factorsClass description: THAP-type zinc fingers follow the signature C- x(2-4)-C-x(35-50)-C-x2-H. Compared with 'canonical' C2H2 zinc fingers, those of THAP type exhibit an unusually long spacing between the first pair of cysteines and the following cysteine-histidine pair, which together coordinate one zinc ion. This long spacer adopts a beta-alpha-beta structure, with the second beta-strand right in front of the third cysteine. An additional short 3,10-helix comprises the zinc-coordinating histidine residue. The two beta-strands form a beta-sheet that inserts into the major groove, whereas the loop following the zinc finger exerts minor groove contacts. (PMID 18073205, PMID 20010837)
More informationSpecies within this Class: 41
Genera within this Class: 12
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DNA binding domain |
Whole protein |
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Phylogenetic tree
Mammalia
These trees (or cladograms, since distances were ignored) were generated with a local installation of PhyML 3.0 (Guindon et al., Systematic Biology, 59(3):307-21, 2010.), by webPRANK at EBI (http://www.ebi.ac.uk/goldman-srv/webprank/), or by the web version of PhyML 3.0 (http://phylogeny.lirmm.fr). The resulting trees were visualized with iTOL v3 (http://itol.embl.de/).
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Phylogenetic tree Mammalia
(slim selection)
To generate these trees, only the TFs were taken from a selected group of mammalian species. As standard, the corresponding human, cow, mouse and Monodelphis TFs were taken if available; occasionally, either species was to replaced or had to be omitted without replacement.
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