About CXXC zinc finger factorsClass description: CXXC zinc fingers contain two zinc ion binding 4-cysteine patterns, each of them comprising a CGxCxxC motif and a distantly located cysteine. One of these patterns (with lower-case Cs) is embedded within the other (with upper-case Cs): C-x(2)-C-x(2)-C-x(5,6)-c-x(2)-c-x(2)-c-x(9,15)-c-x(4)-C. The second and third cysteine of each motif lie within a short alpha-helix. The overall finger structure also forms a two-stranded antiparallel beta-sheet, the two beta-strands being located immediately N- and C-terminally adjacent to the CXXC zinc finger pattern. The CXXC zinc finger binds to DNA at CpG-containing sequences, most of the contacts are exerted by residues of an extended loop in the x(9,15) region of the above signature. (PMID 16990798)
More informationSpecies within this Class: 39
Genera within this Class: 7
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DNA binding domain |
Whole protein |
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Phylogenetic tree
Mammalia
These trees (or cladograms, since distances were ignored) were generated with a local installation of PhyML 3.0 (Guindon et al., Systematic Biology, 59(3):307-21, 2010.), by webPRANK at EBI (http://www.ebi.ac.uk/goldman-srv/webprank/), or by the web version of PhyML 3.0 (http://phylogeny.lirmm.fr). The resulting trees were visualized with iTOL v3 (http://itol.embl.de/).
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