About DM-type intertwined zinc finger factorsClass description: The known transcription factors exhibiting a DNA-binding domain of intertwined zinc fingers belong to the DM group of proteins, named after Drosophila Doublesex and C. elegans Meb-3. Intertwined are one zinc finger of C2HC and one of HCC2 type, each binding one zinc ion. Together, they follow the consensus pattern C--C--h--------H---C----c-c-c, where upper and lower case letter refer to either zinc finger, and dashes symbolize any other amino acid. The most C-terminal cysteine is part of a short alpha-helical structure, which extends into a carboxy-terminal tail that stably folds into an alpha helix upon binding to DNA. This recognition helix binds in the minor groove of the DNA. In contrast to other minor-groove binders, it does not induce a sharp bending of the DNA. (PMID 16382145)
More informationSpecies within this Class: 41
Genera within this Class: 8
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DNA binding domain |
Whole protein |
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Phylogenetic tree
Mammalia
These trees (or cladograms, since distances were ignored) were generated with a local installation of PhyML 3.0 (Guindon et al., Systematic Biology, 59(3):307-21, 2010.), by webPRANK at EBI (http://www.ebi.ac.uk/goldman-srv/webprank/), or by the web version of PhyML 3.0 (http://phylogeny.lirmm.fr). The resulting trees were visualized with iTOL v3 (http://itol.embl.de/).
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Phylogenetic tree Mammalia
(slim selection)
To generate these trees, only the TFs were taken from a selected group of mammalian species. As standard, the corresponding human, cow, mouse and Monodelphis TFs were taken if available; occasionally, either species was to replaced or had to be omitted without replacement.
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