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Classification of Transcription Factors in Mammalia

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  • 2 Zinc-coordinating DNA-binding domains
About DM-type intertwined zinc finger factors
Class description: The known transcription factors exhibiting a DNA-binding domain of intertwined zinc fingers belong to the DM group of proteins, named after Drosophila Doublesex and C. elegans Meb-3. Intertwined are one zinc finger of C2HC and one of HCC2 type, each binding one zinc ion. Together, they follow the consensus pattern C--C--h--------H---C----c-c-c, where upper and lower case letter refer to either zinc finger, and dashes symbolize any other amino acid. The most C-terminal cysteine is part of a short alpha-helical structure, which extends into a carboxy-terminal tail that stably folds into an alpha helix upon binding to DNA. This recognition helix binds in the minor groove of the DNA. In contrast to other minor-groove binders, it does not induce a sharp bending of the DNA. (PMID 16382145) More informationSpecies within this Class: 41 Genera within this Class: 8
DNA binding domain Whole protein
Phylogenetic tree
These trees (or cladograms, since distances were ignored) were generated with a local installation of PhyML 3.0 (Guindon et al., Systematic Biology, 59(3):307-21, 2010.), by webPRANK at EBI (, or by the web version of PhyML 3.0 ( The resulting trees were visualized with iTOL v3 (
  • and iTOL
    Phylogenetic tree Mammalia
    (slim selection)
    To generate these trees, only the TFs were taken from a selected group of mammalian species. As standard, the corresponding human, cow, mouse and Monodelphis TFs were taken if available; occasionally, either species was to replaced or had to be omitted without replacement.
      • and iTOL
      Select species

      Selected the species for which a species report should be shown.

      Expression table
      The table below summarizes the protein expression data from the Protein Atlas. The tissues and cell types are linked to the Cytomer ontology

      The selected tree node is not linked to a gene, no expression data is available.