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Classification of Transcription Factors in Mammalia

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Superclass: , Class: ,
Family: , Subfamily: , Genus: ,
  • 2 Zinc-coordinating DNA-binding domains
About C2H2 zinc finger factors
TRANSFAC® class description C0001: Zinc finger motif of TFIIIA/Krueppel type. Each finger comprises 2 cysteine and 2 histidine residues coordinating one zinc ion, in some cases one histidine is replaced by another cysteine. The zinc ion is essential for DNA-binding. The first half of the finger sequence is generally organized in two antiparallel beta-strands, the second half as an alpha-helix and partly as an 310-helix. Hydrophobic contacts between the beta-strands and the alpha-helix are formed by the conserved phenylalanine and leucine residues. The alpha-helix binds to DNA through the major groove. The finger link frequently is TGEKPY. More informationSpecies within this Class: 41 Genera within this Class: 637
DNA binding domain Whole protein
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Expression table
The table below summarizes the protein expression data from the Protein Atlas. The tissues and cell types are linked to the Cytomer ontology

The selected tree node is not linked to a gene, no expression data is available.