Classification of Transcription Factors in Mammalia

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1 Basic domains
2 Zinc-coordinating DNA-binding domains
- 2.1 Nuclear receptors with C4 zinc fingers
  - 2.1.1 Steroid hormone receptors
  - 2.1.2 Thyroid hormone receptor-related factors
  - 2.1.3 RXR-related receptors
    - 2.1.3.1 RXR(NR2B)
      - 2.1.3.1.1 RXRALPHA (NR2B1)
      - 2.1.3.1.2 RXRBETA (NR2B2)
      - 2.1.3.1.3 RXRGAMMA (NR2B3)
    - 2.1.3.2 HNF4(NR2A)
    - 2.1.3.3 TLX(NR2E1)
    - 2.1.3.4 TR(NR2C)
    - 2.1.3.5 COUP(NR2F)
  - 2.1.4 NGFI(NR4A)
  - 2.1.5 FTZF1related(NR5A)
  - 2.1.6 GCNF(NR6)
  - 2.1.7 DAXrelated(NR0)
- 2.2 Other C4 zinc finger-type factors
- 2.3 C2H2 zinc finger factors
- 2.5 DM-type intertwined zinc finger factors
- 2.6 CXXC zinc finger factors
- 2.7 C2HC
- 2.8 C3H zinc finger factors
- 2.9 C2CH THAP-type zinc finger factors
3 Helix-turn-helix domains
4 Other all-alpha-helical DNA-binding domains
5 alpha-Helices exposed by beta-structures
6 Immunoglobulin fold
7 beta-Hairpin exposed by an alpha/beta-scaffold
8 beta-Sheet binding to DNA
9 beta-Barrel DNA-binding domains
0 Yet undefined DNA-binding domains

General

Species within this Genus: 26 LOGO plot of the DNA binding sequence

Species specific reports

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Ailuropoda melanoleuca

Synonyms: giant panda

Outlinks

Ensembl gene: ENSAMEG00000011124

Bos taurus

Synonyms: cattle, domestic cow

Outlinks

Ensembl gene: ENSBTAG00000017851

Callithrix jacchus

Synonyms: white-tufted-ear marmoset, white ear-tufted marmoset

Outlinks

Ensembl gene: ENSCJAG00000010148

Canis lupus familiaris

Synonyms: dog, dogs

Outlinks

Ensembl: ENSCAFG00000019838

Cavia porcellus

Synonyms: domestic guinea pig, guinea pig

Outlinks

Ensembl gene: ENSCPOG00000000168

Dasypus novemcinctus

Synonyms: nine-banded armadillo

Outlinks

Ensembl gene: ENSDNOG00000044228

Equus caballus

Synonyms: horse, equine

Outlinks

Ensembl gene: ENSECAG00000019365

Felis catus

Synonyms: domestic cat, cats

Outlinks

Ensembl gene: ENSFCAG00000002431

Gorilla gorilla gorilla

Synonyms: western lowland gorilla, lowland gorilla

Outlinks

Ensembl gene: ENSGGOG00000009752

Homo sapiens

Synonyms: human, man

Outlinks

BioGPS: ENSG00000186350
Ensembl gene: ENSG00000186350
ProteinAtlas: ENSG00000186350 ( with antibody)
TRANSFAC: T01345
UniProt: P19793

Protein expression pattern:Show tableIsoforms and DNA binding domain

Ictidomys tridecemlineatus

Synonyms: thirteen-lined ground squirrel

Outlinks

Ensembl gene: ENSSTOG00000028427
UniProt: NA

Loxodonta africana

Synonyms: African savanna elephant, African savannah elephant

Outlinks

Ensembl gene: ENSLAFG00000012239
UniProt: NA

Macaca mulatta

Synonyms: Rhesus monkey, rhesus monkeys

Outlinks

Ensembl gene: ENSMMUG00000008183

Microcebus murinus

Synonyms: gray mouse lemur, grey mouse lemur

Outlinks

Ensembl gene: ENSMICG00000010833
UniProt: NA

Monodelphis domestica

Synonyms: gray short-tailed opossum

Outlinks

Ensembl gene: ENSMODG00000013136
UniProt: NA

Mus musculus

Synonyms: house mouse, mouse

Outlinks

Ensembl gene: ENSMUSG00000015846
TRANSFAC: T01331
UniProt: P28700

Isoforms and DNA binding domain

Mustela putorius furo

Synonyms: domestic ferret, ferret

Outlinks

Ensembl: ENSMPUG00000012176

Myotis lucifugus

Synonyms: little brown bat

Outlinks

Ensembl gene: ENSMLUG00000010476
UniProt: NA

Nomascus leucogenys

Synonyms: northern white-cheeked gibbon, White-cheeked Gibbon

Outlinks

Ensembl gene: ENSNLEG00000008722
UniProt: NA

Ornithorhynchus anatinus

Synonyms: platypus, duckbill platypus

Outlinks

Ensembl gene: ENSOANG00000003910
UniProt: NA

Otolemur garnettii

Synonyms: small-eared galago

Outlinks

Ensembl gene: ENSOGAG00000010970

Ovis aries

Synonyms: sheep, wild sheep

Outlinks

Ensembl gene: ENSOARG00000002366

Pan troglodytes

Synonyms: chimpanzee

Outlinks

Ensembl gene: ENSPTRG00000021527
UniProt: H2R395

Isoforms and DNA binding domain

Pongo abelii

Synonyms: Sumatran orangutan, orang utan

Outlinks

Ensembl gene: ENSPPYG00000019748

Rattus norvegicus

Synonyms: Norway rat, rats

Outlinks

Ensembl gene: ENSRNOG00000009446
UniProt: Q0VJ96

Isoforms and DNA binding domain

Sarcophilus harrisii

Synonyms: Tasmanian devil

Outlinks

Ensembl gene: ENSSHAG00000015645
UniProt: NA

Expression table

The table below summarizes the protein expression data from the Protein Atlas. The tissues and cell types are linked to the Cytomer ontology

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Tissue	Cell type	Expression level	Type	Reliability
adrenal gland	glandular tissue	High	APE	Medium
appendix	glandular tissue	High	APE	Medium
appendix	lymphoid tissue	High	APE	Medium
bone barrow	hematopoetic stem cell	High	APE	Medium
breast	glandular tissue	Medium	APE	Medium
bronchi	ciliated call with propulsive function of respiratory tract	High	APE	Medium
cerebellum	granule cell	High	APE	Medium
cerebellum		Medium	APE	Medium
cerebellum	purkinje cell	Medium	APE	Medium
cerebral cortex	glial cell of central nervous system	Medium	APE	Medium
cerebral cortex	neuron	Medium	APE	Medium
cervix of uterus	glandular tissue	High	APE	Medium
cervix of uterus	squamous epithelial cell	Medium	APE	Medium
colon	glandular tissue	High	APE	Medium
duodenum	glandular tissue	Medium	APE	Medium

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