About Basic helix-span-helix factors (bHSH)TRANSFAC class description C0032: Examining human AP-2 as paradigm of this structural class, a DNA-contacting domain was identified which comprises several clusters of basic amino acid side chains. C-terminally adjacent to it, a dimerization domain was found which consists of two putative alpha-helices separated by a span of over 80 amino acids. This HSH dimerization domain can functionally replace the ZIP dimerization domain of c-Jun. (PMID 1998122)
More informationSpecies within this Class: 40
Genera within this Class: 5
LOGO plot of the DNA binding domain
FASTA file of the LogoPlot
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DNA binding domain |
Whole protein |
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FASTA file |
FASTA file |
Phylogenetic tree
Mammalia
These trees (or cladograms, since distances were ignored) were generated with a local installation of PhyML 3.0 (Guindon et al., Systematic Biology, 59(3):307-21, 2010.), by webPRANK at EBI (http://www.ebi.ac.uk/goldman-srv/webprank/), or by the web version of PhyML 3.0 (http://phylogeny.lirmm.fr). The resulting trees were visualized with iTOL v3 (http://itol.embl.de/).
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