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Classification of Transcription Factors in Mammalia

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Superclass: , Class: ,
Family: , Subfamily: , Genus: ,
  • 1 Basic domains
About Basic leucine zipper factors (bZIP)
TRANSFAC class description C0008: A DNA-binding basic region is followed by a leucine zipper. The leucine zipper consists of repeated leucine residues at every seventh position and mediates protein dimerization as a prerequisite for DNA-binding. The leucines are directed towards one side of an alpha-helix. The leucine side chains of two polypeptides are thought to interdigitate upon dimerization (knobs-into-holes model). The leucine zipper dictates dimerization specificity. Upon DNA-binding of the dimer, the basic regions adopt alpha-helical conformation as well. Possibly, a sharp angulation point separates two alpha-helices of the subregions A and B leading to the scissors grip model for the bZIP-DNA complex. The DNA is contacted through the major groove over a whole turn. More informationSpecies within this Class: 41 Genera within this Class: 53 LOGO plot of the DNA binding domain
FASTA file of the LogoPlot
DNA binding domain Whole protein
Phylogenetic tree Mammalia
(slim selection)
To generate these trees, only the TFs were taken from a selected group of mammalian species. As standard, the corresponding human, cow, mouse and Monodelphis TFs were taken if available; occasionally, either species was to replaced or had to be omitted without replacement.
    • webPRANK and iTOL
    • and iTOL
    Select species

    Selected the species for which a species report should be shown.

    Expression table
    The table below summarizes the protein expression data from the Protein Atlas. The tissues and cell types are linked to the Cytomer ontology

    The selected tree node is not linked to a gene, no expression data is available.