Status
Please wait ...

Classification of Transcription Factors in Mammalia

About TFClass

Search in TFClass:

Searches in the label, ID and external references.

Go to the search of TRANSFAC



Superclass: , Class: ,
Family: , Subfamily: , Genus: ,
General
About Basic domains
TRANSFAC class description C0033: Proteins belonging to this superfamily contact the DNA through a basic region which free in solution has a random structure, but becomes alpha-helically folded upon binding to DNA (PMID 2120592, PMID 2145515, PMID 1312255, PMID 8479534, PMID 7926781). Most prominent classes of this group are the bZIP and bHLH proteins. There is no 'consensus' motif for all basic domains of this superfamily. Even the basic regions of bZIP and bHLH factors diverge greatly, although their mode of interacting with the DNA is strictly homologous: A specific alpha-helical dimerization domain provides the linkage between two DNA-contacting basic regions which adopt helical conformation when their positively charged side chains are neutralized by the phosphate backbone of the DNA.Species within this Superclass: 41 Genera within this Superclass: 172
Select species

Selected the species for which a species report should be shown.

Expression table
The table below summarizes the protein expression data from the Protein Atlas. The tissues and cell types are linked to the Cytomer ontology

The selected tree node is not linked to a gene, no expression data is available.